Transcriptomics Bioinformatics for Precision Medicine

Unlock the power of the post-genomic era with this advanced course at UC San Diego.

Building upon the foundations of Processing Actionable Data in Genomics , this course provides students with the technical expertise to navigate the complexities of transcriptomics, a driving force in modern precision medicine.

Since the completion of the human genome sequence, the scientific community has shifted toward understanding genomic variation and annotating protein-coding gene sequences.

Because the annotation of genes relies heavily on transcript identification, mastering transcriptomics is essential for anyone looking to contribute to the fields of genomics and personalized healthcare.

Students will gain hands-on experience with industry-standard bioinformatics pipelines, learning to process both short-read datasets (Illumina) and long-read datasets (PacBio and Oxford Nanopore Technologies) to keep pace with current technological trends.

Learning Outcomes By the end of this course, students will be able to: Implement up-to-date bioinformatics pipelines to process complex transcriptomics data.

Distinguish between and process short-read (Illumina) and long-read (PacBio/Oxford Nanopore) datasets.

Execute splice-aware alignment to accurately map RNA-seq data.

Perform transcript assembly and quantification.

Conduct differential transcript level comparisons to identify significant biological variations.